Excessive amounts of sugar damage the brain partly because it forms toxic compounds called ‘Advanced Glycation End-products’, or AGEs and also because of the harmful effects of too much insulin, the hormone that is released when your blood sugar levels goes high. Think of glucose, or blood sugar, as high-octane fuel. The goal of good nutrition is to deliver ‘slow-releasing’ carbohydrates that gradually break down into pure glucose fuel, which seeps into the bloodstream and is then escorted into cells to help keep your energy high. Too much glucose overloads brain cells, called neurons, which are less capable of dealing with the overload than muscle cells. This is called glucose neurotoxicity. 1 This is backed up by studies that show higher blood glucose levels are associated with less functioning brain tissue in critical areas of the brain. 2
The hormone insulin escorts glucose into cells, either ensuring hungry cells get their due, or dumping excess glucose into storage. It’s a careful balancing act, and one that’s likely to go wrong if you keep eating sugary or reﬁned carbohydrates. The more you eat these the higher your insulin levels and the more often you’ll have peaks in your blood sugar levels, followed by troughs. And this seesawing will leave you tired and unable to concentrate, eventually experiencing ‘blank-mind’ episodes and fading memory. Gradually your body will become less and less responsive to its own insulin – and develop ‘insulin resistance’. Someone in the grip of insulin resistance will produce more insulin in an attempt to get a response, a condition known as hyperinsulinemia, and get rebound blood sugar lows (hypoglycemia). Eventually, they will become so insulin resistant their blood sugar levels don’t go down as they should. Type 2 diabetes is the result.
The bitter truth about sugar
So, what’s all this got to do with preventing Alzheimer’s? The answer is everything. Being insulin resistant or diabetic, having hyperinsulinema or hypoglycemia, have all been shown to tremendously increase a person’s risk of developing Alzheimer’s or dementia.
There are probably many reasons why an upset in blood sugar control damages the brain, but one that stands out is the fact that occasional blood sugar peaks actually sugar-coat proteins, and damage them, creating damaged AGEs. A lifetime of sugar abuse, glycation (adverse interactions between glucose and proteins, for instance) and AGE creation lead to more and more artery and brain damage. The more the arteries become damaged, the worse the circulation to the brain and the less reliable the supply of nutrients becomes. So, ironically, eating too much sugar can lead to temporary glucose starvation to cells, as well as damage caused by excess glycation.
AGEs are not only bad for the brain – they also damage your skin, producing wrinkles and age spots. These damaged proteins produce 50 times the number of free radicals that non-glycated proteins do, and promote inﬂammation in the brain as well as the skin, joints and other organs.
So oxidants and AGEs constitute a double whammy for your brain. Researchers now believe that AGEs may be a player in Alzheimer’s disease because they have been found in the neuroﬁbrillary tangles that characterise the condition, and the formation of beta-amyloid plaque is signiﬁcantly accelerated by the presence of AGEs.
The glucose/Alzheimer’s link
There has been much research into the links between blood sugar and Alzheimer’s. For example, researchers at Columbia University in New York studied 683 people without dementia who were 65 years or older for ﬁve and a half years. During that time, twice as many of the participants with high insulin levels developed dementia when compared to those with normal insulin levels. Also, the people with high insulin levels had the greatest decline in memory. 3 An Italian study of people free of dementia and diabetes showed that high insulin levels were strongly associated with poorer mental function. 4
Meanwhile, a six-year Swedish study of 1,301 people aged 75 and over showed that those with diabetes were one and a half times more likely to develop dementia. The risk was even greater in diabetics who also had high blood pressure or heart disease. 5 A number of other studies have also shown a strong association between diabetes and cognitive decline. 6
Having diabetes increases dementia risk by 20%. 7 Having a higher blood glucose (6.4 vs 5.5mmol/l) increases risk for dementia by 18 per cent. Diabetics with higher blood glucose levels (10.5 vz 8.9mmol/l) have a 40 per cent increased risk. 8
One of the best measures of your blood sugar control is something called glycated haemoglobin. You want to have a score below 5.5 per cent. Researchers at the University of California, San Francisco, studied 1983 postmenopausal women and found those with glycosylated haemoglobin levels of 7 per cent or higher were four times more likely to develop mild cognitive impairment or dementia. 9
‘We suggest the term “Type 3 diabetes” to account for the underlying abnormalities associated with Alzheimer’s dementia-type of neurodegeneration,’ says Suzanna delaMonte in the European Journal of Neuropharmacology reviewing the evidence last year. 10
Why sugar is addictive
It’s one thing to know that sugar is bad for your brain, but another to quit eating it – especially when the desire for something sweet is one of the body’s strongest instincts. Your body and brain are much more responsive to deﬁciency than to having too much. There’s a simple reason for this. In evolutionary terms, starvation is a much more likely, and threatening, situation than today’s danger of excess. Consequently, we are all programmed to ......
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