The discovery has been hailed as “a major step towards Alzheimer’s prevention” by pharmacology professor David Smith.
He first discovered that supplemental B vitamins (B6, B12 and folic acidWhat it does: Critical during pregnancy for the development of a baby’s brain and nerves. Also essential for brain and nerve function. Needed for utilising…) at higher levels than can be achieved through diet, to those with sufficient omega-3 fats, stopped accelerated brain shrinkage, the hallmark of Alzheimer’s[i]
“The effect is greater than that of any drug treatment to date” said Smith.
Combining B Vitamins with Omega-3
A Dutch trial has reported no benefit from the B vitamins in those with low omega-3 status, but a massive improvement in cognition in those with sufficient omega-3 levels.[ii]
A Swedish trial giving omega-3 fish oils to older people found the group with sufficient vitamin B, indicated by a low level of blood homocysteineHomocysteine is an amino acid found in the blood. Elevated levels of homocysteine have been associated with narrowing and hardening of the arteries, an increased…, showed three times the clinical improvement reported from the recent Lecanemab anti-amyloid drug trial.[iii]
A Chinese trial found greatest improvement in those supplementing both omega-3 and the B vitamin folate.[iv] Almost half of all people over 65 have raised homocysteine[v] which increases risk for dementia by up to ten times, according to recent research[vi].
It’s the combination of enough omega-3 and B vitamins that cuts the rate of brain shrinkage, which is the hallmark of Alzheimer’s, by up to 73 per cent.
Award-winning medical journalist Jerome Burne has improved his memory with the combo of B vitamins and omega-3 plus lifestyle changes. “I’ve got skin in the game when it comes to Alzheimer’s. Twenty years ago, I discovered I had a copy of the gene that boosted my chance of developing this awful disease.” Says Jerome, age 75. Optimising omega-3 and B vitamin levels appear to negate the risk of this gene. Upgrade your Brain is the first book that offers hope with the revolutionary idea that diet and lifestyle can help to Alzheimer’s-proof your brain. It clearly explains the largely unfamiliar biology that makes this possible. It’s like Zoe for the brain.” says Jerome.
What Next? Upgrade your Brain AND Become a Citizen Scientist
Thanks to already well over 400,000 ‘citizen scientists we have, with the sword of digital technology, opened the oyster to uncover the true causes – all under your control – that are driving this terrible and unnecessary brain shrinkage.
Those citizen scientists have taken the time, often initially for personal interest, to discover their actual cognitive function, and completed a comprehensive questionnaire.
We hope to reach a million people around the world within a year or so making this the biggest prevention-focussed study of its kind.
Change is not going to come from the Government or the NHS. It is going to have to come from us, the people.
We ask you to take control of upgrading your brain and in the process become Citizen Scientists for better brain health for future generations.
Follow these seven steps.
STEP 1: Take the Cognitive Function Test
What you’ll learn:
- Find out where you are on the cognitive function scale
- Learn the most important dietary and lifestyle actions you can take
- Take control of your mental wellbeing
- Contribute to the Food for the Brain research process
Take the Cognitive Function Test
STEP 2: Test for the Four Keystone Biochemical Processes
A consensus of world experts concluded that lowering homocysteine with B vitamins is the easiest and most cost effective prevention action, which Oxford University’s health economists estimate would save the UK £66 million per year.However, it’s vital to test both homocysteine and Omega-3 levels, as they are co-dependent. Homocysteine-lowering B vitamins only work in those with sufficient omega-3, and omega-3 only works if homocysteine is low.
So, get tested for the four keystone biochemical processes with the DRIfT Test.
It will calculate your Dementia Risk Index functional Test (DRIfT) score. Tracking this, along with your Cognitive Function (CFT) and Dementia Risk Index (DRI) is the most comprehensive way to protect your brain.
This 4-in-1 test measures:
- Vitamin DWhat it does: Helps maintain strong and healthy bones by retaining calcium. Deficiency Signs: Joint pain or stiffness, backache, tooth decay, muscle cramps, hair loss….
- Omega-3
- Homocysteine
- HbA1C
More info – Drift Test from Food for the Brain and Other Tests.
STEP 3 – Get Educated
Read my book Upgrade Your Brain – Out Now!
More info & to order – Upgrade Your Brain Book
Join me on my UK or Ireland Seminar Tour – May/June
I’m visiting 30 cities in the UK and Ireland in May/June to kick start a nationwide ‘Upgrade Your Brain’ campaign.
“We need to engage with millions of people, get nutrition education happening in schools, and most of all get heath authorities and governments around the world to take the mental health meltdown seriously and put brain health at the top of the health agenda.”
Professor Crawford says “Today’s diet bears no resemblance to the wild foods we ate during our species’ evolution to which our genome is adapted. If we don’t prioritise brain health and nutrition the continued escalation of mental ill health, starting in the 1950s, can only end in disaster.”
Dates/locations: More tour info & how to book
Sign up to my E-News
Go to the home page of this website and sign up to my E-News for more blogs/reports/videos and podcasts on brain health. Follow on Facebook (PatrickHolford) and Instagram. (PatrickHolford.UK)
STEP 4: Start a Brain Healthy Diet
The Upgrade Your Brain cooking app with brain-friendly recipes will be launching soon. It will help you make the right food choices for your brain.
STEP 5: Ensure You Get Enough of the Right Nutrients
There are three essentials for building brain cells (neurons) – omega-3 fats, B vitamins and Phospholipids. Omega-3 is bound to phospholipids by methylationMethylation is what occurs when the body takes one substance and turns it into another, so that it can be detoxified and excreted from the… which is a process that is dependent on B vitamins – B6, B12 and folate.
There are some key supplements that have been identified to support brain health. In the Holford range these are:
- Connect: B vitamins and zincWhat it does: Component of over 200 enzymes in the body, essential for growth, important for healing, controls hormones, aids ability to cope with stress… to support healthy methylation
- High PC Lecithin – A Rich source of 63% phospholipid
- Omega-3 Support – 550mg of DHADHA is short for Docosahexaenoic Acid. It is an essential omega-3 fatty acid found in fish such as salmon, mackerel and herring, and is often… and 750mg of EPAEPA is short for Eicosapentaenoic Acid. It is an essential omega-3 fatty acid found in fish such as salmon, mackerel and herring, and is often…
All these are found in the Brain Food Upgrade pack
STEP 6: Spread the Word & Promote Prevention
We urge everyone to share the ‘prevention’ message with others.
You can do this by sharing social media posts and blogs/reports.
You can participate in Alzheimer’s Prevention Day on 15 May and encourage others to do the same. Take the free 3-minute online Alzheimer’s Prevention Check and get motivated to make the eight brain-friendly diet and lifestyle changes
“You are the architect of your own brain’s future health.” says neurologist Dr David Perlmutter.
Take the test for Alzheimer’s Prevention Day
Step 7: Support the ‘Prevention’ Work
‘Friends’ donate £50 a year and get so much in return. This is how we are funding our amazing research team (see foodforthebrain.org/researchteam/). We are a lean, keen, small but mighty team.
Every donation, big or small, goes right back into helping people prevent these preventable and terrible diseases such as dementia. Together, we can change the world. We need to, because time is running out. We will lose our humanity if we don’t stop this brain drain.”
All donations are put back into research, and the results of the research are shared back to people.
Give to Food for the Brain and support their work.
REFERENCES
[i] Jernerén F, Elshorbagy AK, Oulhaj A, Smith SM, Refsum H, Smith AD (2015). Brain atrophy in cognitively impaired elderly: the importance of long-chain ω-3 fatty acids and B vitamin status in a randomized controlled trial. Am J Clin Nutr. 2015 Jul;102(1):215-21
[ii] van Soest, A.P.M., van de Rest, O., Witkamp, R.F. et al. DHA status influences effects of B-vitamin supplementation on cognitive ageing: a post-hoc analysis of the B-proof trial. Eur J Nutr (2022). https://doi.org/10.1007/s00394-022-02924-w
[iii] Walsh S, Merrick R, Richard E, Nurock S, Brayne C. Lecanemab for Alzheimer’s disease. BMJ. 2022 Dec 19;379:o3010. doi: 10.1136/bmj.o3010. PMID: 36535691.
[iv] Li M, Li W, Gao Y, Chen Y, Bai D, Weng J, Du Y, Ma F, Wang X, Liu H, Huang G. Effect of folic acid combined with docosahexaenoic acid intervention on mild cognitive impairment in elderly: a randomized double-blind, placebo-controlled trial. Eur J Nutr. 2021 Jun;60(4):1795-1808. doi: 10.1007/s00394-020-02373-3. Epub 2020 Aug 28. PMID: 32856190.
[v] Pfeiffer CM, Osterloh JD, Kennedy-Stephenson J, Picciano MF, Yetley EA, Rader JI, Johnson CL. Trends in circulating concentrations of total homocysteine among US adolescents and adults: findings from the 1991-1994 and 1999-2004 National Health and Nutrition Examination Surveys. Clin Chem. 2008 May;54(5):801-13. doi: 10.1373/clinchem.2007.100214. Epub 2008 Mar 28. PMID: 18375482.
[vi] Teng Z, Feng J, Liu R, Ji Y, Xu J, Jiang X, Chen H, Dong Y, Meng N, Xiao Y, Xie X and Lv P (2022) Cerebral small vessel disease mediates the association between homocysteine and cognitive function. Front. Aging Neurosci. 14:868777. doi: 10.3389/fnagi.2022.868777
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