For this reason scientists from the Genomics Research Centre (GRC) at Griffith University in Brisbane decided to investigate the impact of giving migraine sufferers supplements of homocysteine lowering B vitamins (B6, B12 and folic acid). They recruited 52 people diagnosed with migraine. The participants were randomly assigned to receive either vitamin supplements providing a daily dose of 2mg of folic acid, 25mg vitamin B6, and 400 micrograms of B12, or placebo, for six months. These levels are at least 10 times RDA levels. Results showed a reduction in homocysteine levels by 39 per cent, compared to baseline, and statistically significant compared to placebo. Furthermore, the supplements were associated with a reduction in the prevalence of migraine disability from 60 per cent at the start of the study to 30 per cent after 6 months. No reduction was observed in the placebo group, said the researchers. Previous research had shown that vitamin B2, another important factor for healthy methylation, also reduces migraines. So, if you suffer from migraines it’s well worth your while known your homocysteine level, which can be tested on a home test kit, and possibly taking a supplement containing all the key nutrients for methylation (B2, B6, folic acid, B12, TMG and zinc). If you suffer from migraines what else have you found that works?