£20m to Push Failed Drugs with no Talk of Prevention

Today, the Guardian announced a £20 million scheme, funded by the Medical Research Council (MRC), to fast track drugs that don’t work – with no talk of prevention.

They report that the chief executive at Alzheimer’s Research UK said it was incredibly disappointing that NHS patients would not have access to either of the two anti-amyloid drug treatments, rightly rejected by NICE.

“While these drugs are not cures and come with risk of side-effects, trials show they are the first treatments to slow the decline in memory and thinking skills linked to Alzheimer’s, rather than just alleviating symptoms.” Said ARUK’s Hilary Evans-Newton.

But this is not true. The Oxford University trial of homocysteine lowering B vitamins, especially in those with sufficient omega-3 status, confirmed by other studies, showed three times the clinical benefit, with up to 73% reduced rate of brain shrinkage, compared to Donanemab, which increase the rate of brain shrinkage.

Several people died in the anti-amyloid trials, with over a quarter getting brain bleeding and swelling. Professor Paul Morgan, of the UK Dementia Research Institute Cardiff, described these drugs as “eye-wateringly expensive, difficult to administer and potentially harmful”. Is it really ethical to keep going down the defunct and dangerous anti-amyloid drug pathway?

We badly need a robust trial of the combination of homocysteine lowering B vitamins and omega-3 fish oils. Leading UK neurologists have been trying to get the £3 million needed to run such a definitive prevention trial – but MRC aren’t interested. ARUK allocate less than 5% of funds raised for non-drug prevention.

If you’d like to help make dementia prevention a reality become a Friend of foodforthebrain.org and write to your MP because it is tax payers money that is being spent pushing failed drug treatments.