Dr Yian Gu of Columbia University Medical Center, New York, and colleagues studied 2,148 older adults (age 65 and older) without dementia living in New York. Participants provided information about their diets and were assessed for the development of dementia every 1.5 years for an average of four years. Several dietary patterns were identified with varying levels of seven nutrients previously shown to be associated with Alzheimer’s disease risk: saturated fats, monounsaturated, omega-3 and omega-6 fats, vitamin E, vitamin B12 and folate. During the follow-up, 253 individuals developed Alzheimer’s disease. One dietary pattern was significantly associated with a reduced risk of the disease. This pattern involved high intakes of salad dressing, nuts, fish, tomatoes, poultry, fruits and cruciferous and dark and green leafy vegetables and low intakes of high-fat dairy, red meat, organ meat and butter. The combination of nutrients in the low-risk dietary pattern reflect multiple pathways in the development of Alzheimer’s disease, the authors note. “For example, vitamin B12 and folate are homocysteine-related vitamins that may have an impact on Alzheimer’s disease via their ability of reducing circulating homocysteine levels, vitamin E might prevent Alzheimer’s disease via its strong antioxidant effect and fatty acids may be related to dementia and cognitive function through atherosclerosis, thrombosis or inflammation via an effect on brain development and membrane functioning or via accumulation of beta-amyloid,” they write. These findings are completely consistent with out recent 100% Health Survey and the diet I recommend in the Alzheimers Prevention Plan book. These principles are also incorporated into the Holford Diet which also factors in eating a low GL diet. In our 100% Health survey we found that the consumption of sugar-based snacks and sugar were strongly associated with worsening memory and concentration. All the other findings in this recent study, soon to be published in the Archives of Neurology (Arch Neurol. 2010;67), are completely consistent with our survey results.