The good news is that there are two simple actions you can take right now that have been shown to stop the brain shrinking and keep your memory sharp. According to researchers at the US National Institutes of Health (NIH) researchers these two simple actions account for up to 44% of the risk for Alzheimer’s and, of all the prevention steps you can take to cut your risk, are the easiest for you to action.
1. Keep your homocysteine level below 10mcmol/l with B vitamins
2. Ensure an optimal intake of omega-3 fats According to a robust double-blind, placebo controlled trial at the University of Oxford, those with declining memory, a raised homocysteine level, supplementing B vitamins resulted in 73% less brain shrinkage in one year, compared to placebo provided they had sufficient intake of omega-3 fats.
The point here is that you need both an optimal intake of omega-3 fats and enough B vitamins to keep your homocysteine down. If you read my recent special report ‘ How to Boost Your Intelligence’ you’ll know that your brain cells (neurons) are made out of a combination of omega-3 fats (mainly DHA) attached to phospholipids, and that the linking of these two depends on B vitamins required for healthy methylation, which is what the blood test homocysteine measures. If your H score is high it means you don't have enough B vitamins for healthy methylation.
Omega-3 fats keep your brain healthy & memory sharp
The average person in the UK consumes 1 to 2 fish servings per week (217g). According to the NIH researchers low fish/omega-3 intake versus high fish consumption accounts for 22% of Alzheimer’s cases and is associated with reduced brain volume. Hence, the more fish you eat the more healthy grey matter there is in the brain. Another survey found that eating one serving of oily fish a week was associated with halving the risk of Alzheimer’s.
Supplements of one key essential fat found in omega-3 fish oil, called DHA, have been shown to enhance memory in adults  who don’t eat fish, and to prevent memory loss in those in the early stages of memory decline. Studies giving supplemental omega-3 fish oils have shown improved cognition in older people and positive structural changes in the brain. Overall, what the studies to date show clearly is that memory significantly improves in people with or without mild memory complaints if given omega-3 supplements providing DHA/EPA at a daily intake of 1 gram of EPA/DHA or more.
Also, having more omega-3 fats from diet has been shown to link to increase blood brain flow, according to researchers at the University of South Dakota School of Medicine. They selected a group of participants and found that the higher their omega-3 level in the blood the better was their blood brain flow rate, which is a hallmark of enhanced memory. According to study co-author William Harris "this raises the possibility that higher omega-3 EPA&DHA fatty acid level can improve underlying brain physiology that may in turn translate to better cognitive reserve".
Omega-3s may also protect the brain from amyloid plaque. The accumulation of amyloid protein, leading to the formation of ‘sticky’ amyloid plaque that stops the brain working, has long been argued to be a cause of memory loss and drugs, unsuccessfully, have targetted blocking amyloid formation. However, a small trail giving people both omega-3 and antioxidants has shown improved clearance (phagocytosis) of amyloid deposits in the brain.
There’s another good reason to supplement omega-3 fish oils. Doing so may lower your homocysteine, which is the second proven memory protector. A meta-analysis of eleven trials in which people were given omega-3 fish oil capsules, the average drop in homocysteine was a significant 1.6 mcmol/l.
While fish oil capsules only provide omega-3, eating oily fish gives you other nutrients, including the vital vitamin B12 that is the lynchpin of healthy methylation. But it’s not just oily fish. The more fish you eat, the better your memory test performance. All fish are also excellent sources of vitamins B12 , D and choline, all essential for the brain.
My strong advice is to both eating three servings of oily fish a week, and supplement over 550mg of combined EPA&DHA. This will give you the equivalent of 2 grams of omega-3, providing close to 1g of EPA&DHA a day, which is optimal for brain protection. This is what I eat and take with my two daily essential omega capsules.
Keep your homocysteine low with B vitamins
A high blood homocysteine level, which is the best way to know if you’re getting enough B vitamins for healthy methylation, is known to increase the rate of brain shrinkage. You want to keep your ‘H’ score below 10mcmol/l. Something like one in three people over age 60 have an H score higher than this and are therefore at risk of dementia later in life. This risk factor is estimated to account for 22% of Alzheimer’s disease according to the US National Institute of Health researchers.
Giving B6, B12 and folic acid supplements to people with high homocysteine has already shown a nine-fold reduction in brain shrinkage and a substantial reduction in rate of memory loss (cessation in some cases). This is the only proven disease-modifying treatment to date and is thus the strongest prevention factor.
In an enlightened health service we would screen people from aged 50 for the first signs of cognitive impairment and, if present, measure homocysteine and, if ......
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