The brain’s origin, for all species, is from the ocean. It had to be as that is where life began. Millions of years ago the rudimentary eye cell, dinoflagellate, which is a type or marine phytoplankton, used a specific fat – the omega-3 fat docosahexanoic acid (DHA) – to convert solar photon energy into the first nerve impulse or twitch - a twitch towards food. That is the origin of the nervous system and brain.
Back in the ‘80’s, when biochemist Professor Michael Crawford, Fellow of the Royal College of Pathologists, analysed the types of fat in different animal’s organs and muscles they varied according to their dietary environment, except the brain.1 He discovered that the brain is always rich in DHA. The more DHA the brighter the animal, with the sea mammals and us humans having exceptionally high levels.There is no doubt that DHA is a vital constituent of the human brain and played a role in it's evolution.2
Recently it has been proven that DHA (docosahexanoic acid) has a unique structure involving six double bonds, arranged in a horseshoe shape, which actually makes it a semi-conductor with unique electrical properties.3 Its close cousins, ALA (alpha linolenic acid) in chia or flax, and EPA (eicosapentanoic acid) don’t have this potential. It’s all about DHA. While some EPA converts into DHA less than 1 per cent of ALA in plant-based sources of omega-3 such as chia seeds converts to DHA, the richest source of which is marine-based food from rivers and the sea.
Somewhere between 7 and 6 million years ago our hominid ancestors split from other apes (chimps, gorillas and bonobos), culminating in Homo Sapiens around 100,000 years ago. It clearly wasn’t genes that made us different. We share 98.5% of the same genome. It had to be the environment our ancestors exploited. During this time brain size steadily increased up to 1.45kg 10,000 years ago, roughly three times the size of a chimpanzee, at 384g.
This happens to coincide with a shift in tectonic activity in East Africa, 6.7 million years ago, with inundation of the sea from the Gulf of Aden down to Mozambique and formation of the Great Rift Valley. It eventually resulted in a series of shallow salt water lakes which is precisely where the early Australopithecine and other fossils were found. This would have been an ideal source for their DHA. Because these marine lakes were inland, the fossils were preserved and not subject to the rising level of the sea, wave damage and dispersion as the coastal settlements would have been after the end of the ice ages with rising sea levels.
We have over twenty profound anatomical, physiological and biochemical differences apart from our vastly different psychological advancement as in intelligence and language. More than anything, it is this, illustrated by our brain size, that makes us different. But, before looking closely at the circumstances, and diet, that almost certainly drove our gain in brain size and intelligence, let’s take a look at the fundamental differences we have. These have been so clearly delineated in an excellent book,
The Waterside Ape, by Peter Rhys-Evans, and ear, nose and throat surgeon. He explores why we:
- Stand upright
- Have (virtually) no body hair
- Have a layer of sub-cutaneous fat
- A waxy, waterproof layer, the vernix, at birth
- A diving reflex at birth, meaning we are able to swim before we can walk, and hold our breath underwater
- A descended larynx, a precursor of being able to have complex language/speaking
Enlarged sinus cavities
- A nose shape that is good for keeping the water out while swimming
- Ears that actually form a protective boney protusion in those who spend a lot of time diving
- Different kidneys, in how they filter salt and water
- Manual dexterity
- Crinkly fingers when in water for a few minutes
Of course, the story we’ve all been told is that we came out of the trees, into the savannah and stood upright for better hunting. Anyone who has been on safari will know that a) you don’t stand a chance catching anything by standing upright – you crawl; and b) all the good hunters can sprint much faster than man (lion 80kph, leopard 60kph, cheetah 100kph, man under 30kph) precisely because four legs are better than two. But, can you explain any one of these other changes, let alone our increase in intelligence, by moving from the trees into the savannah for hunting? If so, how did we suddenly develop manual dexterity, tools and spears overnight to even survive? Also, why do certain ‘sea nomad’ tribes exist, such as the Moken and Bajou, who can hold their breath for up to 10 minutes under water, spending up to five hours a day in the sea, giving birth in the sea? Their spleen is adapted to oxygenate tissue, as it is in dolphins, to enable long dives. Where did that evolutionary adaptation come from?
The only logical explanation that I have encountered, which eloquently fits all these adaptations, in that our hominid ancestors exploited the waterside – wetlands, swamplands, rivers, estuaries and coasts. In the process of so doing, became upright, and started to eat a diet high in marine foods, providing the essential nutrients for brain development, that is omega-3 DHA, phospholipids, plus vitamin B12, iodine, and all those other essential elements from magnesium to selenium. From this perspective let’s briefly examine all the changes listed above, between us and other apes:
- Stand upright – better for wading in water, so gradually our anatomy adapts but, even so, we are prone to the problems of uprightness, eg hips and knees because it is anatomically inferior to walk on all fours, with better weight distribution.
- Have (virtually) no body hair and a layer of sub-cutaneous fat – consistent with semi-aquatic mammals better for floating and insulation
- A waxy, waterproof layer, the vernix, at birth – found in no land mammals, only other semi-aquatic mammals such as seals - and chemically identical to that of seals.
- A diving reflex at birth, meaning we are able to swim before we can walk, and hold our breath underwater
- A descended larynx, a precursor of being able to have complex language/speaking – being upright, and diving, could have led to this vital adaptation. This, by the way, only occurs after a year or so, before which a baby’s language cannot develop the complexity of sounds and voice control only we have
- Enlarged sinus cavities, which help to keep the head above water, but still have drainage holes in the ‘wrong’ place, eg good if on all fours but bad if upright, which is why we are prone to sinus problems.
- A nose shape that is good for keeping the water out while swimming
- Ears that actually form a protective boney protusion in those who spend a lot of time diving
- Manual dexterity – if we were wading, and swimming, not walking on all fours, we have ‘free’ hands. Opening shells would develop manual dexterity.
- Crinkly fingers when in water for a few minutes – perfect for catching fish.
Part of the idea of the ‘savannah’ theory is that food became scarce with climate changes so we switched to hunting. But the water’s edge was, until recently, abundant with easily accessible food. Even 200 years ago, in 1706, Daniel Dafoe wrote this regarding the Firth of Forth. “Off the Pentland Firth the sea was one third water and two thirds fish; the operation of taking them could hardly be call’d fishing, for they did little more than dip for them into the water and take them up.” Our estuaries were packed with mussels, oysters and crabs.
Historically, wherever early man is found so too is evidence of seafood consumption, with remains of shells, fish bones etc. from Pinnacle Point in South Africa, where early remains are found together with sea shells, to Wales. When a 40,000 year old Homo sapiens was found in the Gower peninsular DNA evidence showed that a quarter of their diet was seafood.
A marine food diet high in critical brain building nutrients, especially DHA, phospholipids and B12, is the best explanation for our cerebral expansion. "Docosahexaenoic acid (DHA), the omega-3 fatty acid that is found in large amounts in seafood, boosts brain growth in mammals. That is why a dolphin has a much bigger brain than a zebra, though they have roughly the same body sizes. The dolphin has a diet rich in DHA. The crucial point is that without a high DHA diet from seafood we could not have developed our big brains. We got smart from eating fish and living in water.” says Crawford.
The dry weight of the brain in 60 per cent fat and DHA makes up over 90 per cent of the structural fat of neurons (brain and nerve cells). The intelligent membrane that makes up all neurons is composed of phosphorylated DHA – that is DHA attached to phospholipids. The most abundant phospholipid is phosphatidyl choline, found predominantly in fish, eggs and organ meats. These are bound together by a process called methylation, itself dependent on vitamins B12, folate and B6. While folate and B6 is found in both plant foods and seafood, B12 is only found in foods of animal origin, and is especially high in all marine foods.
The evidence that exists suggests we were eating a diet rich in marine food, as well as plant foods along the water’s edge, enjoying the ‘fruité del mare’. We would have eaten much more than we do today – at least double the calories. Today’s convenience world has dramatically reduced the calories we need to expend hunting and gathering food, travelling and staying warm.
The idea that we were eating twice as much and at least a quarter from marine foods makes sense of what we know about the optimal intake of both omega-3 fats rich in DHA, phospholipids and vitamin B12, lack of which are the main drivers of today’s endemic dementia. This would be equivalent to at least half our diet today needing to be from marine foods rich in fats.
Optimal amounts of omega-3 from seafood is estimated at 2 grams a day by Joseph Hibbeln at the US National Institute’s of Health, while choline is estimated at 400mg to 800mg. An optimal intake of B12 is probably 10mcg. These can be achieved by eating at least seven servings of oily fish a week. (Choline is rich in all fish, but DHA is only rich in oily fish, fish roe and liver, while B12 is rich in all sefood.)
In the chart below the last column combines EPA and DHA and shows the amount provided in an 85g serving. None provide 2,000mg, although they do get close, suggesting that we would have needed to eat at least a serving of fish or seafood a day, if not more.
Brain size remains reasonably constant from 100,000 to 10,000 years ago, then starts to shrink, perhaps coinciding with the birth of agriculture and diets based more on meat, milk and plants than marine foods. Today, average brain size is 1.35kg.
The evolution of intelligence and self-awareness
Apart from brain size and, more pertinently, brain to body size ratio, what sets us apart from other animals is self-awareness. Animals have the equivalent of thoughts and feelings but humans are relatively unique in being able to witness one’s own thoughts and feelings, that is self- awareness. This is not an easy thing to measure, but some other mammals, notably dolphins, gorillas and chimpanzees, also have a degree of self-awareness. Other contenders for higher cognition include octopuses and elephants, all large brained creatures. However, it isn't just size that counts. In essence, there are three evolutions of the brain. First, the reptilian brain located on the brain stem, which programmes basic survival needs. Then there’s the mammalian brain, with more cognitive and emotive functions (think dog), then the neo-cortex, associated with higher cognition. But, while elephants have larger brains they have smaller neo-cortexes. It’s the neo-cortex that starts to grow in our hominid ancestors.
An indication of an advancing intelligence could be supposed from the earliest evidence of ancient rock art, as well as use of complex tools and adornments, and the emergence of music and religion.
The earliest rock art is found in South Africa, dating back 77,000 years ago, and in Western Europe about 37,000 years ago, and possibly in Australasia (Sulawesi) around that time.
The richest concentration of ancient rock art over 6,000 years ago, however, is found in sub-Saharan Africa, the Nile Valley and Red Sea hills, then a green belt with vast lakes, rivers and wetlands, hence abundant marine foods, which lasted until about 3,500 years ago when much of Egypt is becoming a desert. Whether the drying up of the Sahara was linked to the Younger Dryas (see below), a change in the Earth’s tilt or over grazing is a subject of debate.4
Meanwhile, groups of our early ancestors who had left Africa, living in Europe as far west as Ireland, north as Scandinavia, East as China and Australia, were also struck by cataclysmic weather changes. In Europe the Magdalenian culture, with advanced stonework, exists from 17,000 years ago, coinciding with the end of the Ice Age, until 12,000 years ago, coinciding with the Younger Dryas, a period of extreme cooling which lasted for circa 1,000 years, possibly triggered by a meteor shower5. One theory has ancestors migrating south, towards warmer climates with available water, possibly carrying with them the sticky grains they had previously gathered, and may have planted them in moist soil as a means to survive, thus giving birth to the agricultural age whereby mankind moves away from a hunter gatherer lifestyle towards an agricultural lifestyle. This also makes sense as these two pockets of humanity, in Mesopotamia (now Iraq), between the Tigris and Euphrates river, and Egypt, as they become more densely populated thus with the need for stored food, supplied by grains and domesticating animals. This stable food supply would have allowed expansion of these populations. (There is another evolutionary hotspot in Asia and China6.)
The likely existence of an ‘enlightened’ culture, Atlantis, is eluded to in the writings of Plato, possibly existing around the fertile region of the then much smaller Black Sea, which is thought to have flooded across the Bosphorus peninsular when the Mediterranean sea levels rose to a critical mass, dated back to around 7,000 years ago. This may also be the origin of the Flood myth, which occurs in ancient Sumerian lore dating back 5,000 years and later Hebrew lore.
Thus we have this triangle between the Black Sea to the North, Egypt to the South, and Mesopotamia to the East, all with evidence of evolved culture, including monotheism. The Sumerian culture appears over 6,000 years ago in the fertile crescent of Mesopotamia. Later, circa 2,500 years ago, we have the enlightened Zoroastra in Mesopotamia forming the Parsi culture in what is now Iran. Also,The Aryan-(Dru)Vedic culture, sometimes located east of the Black sea, migrated into the Indus valley in northern India as the main influence of the now Hindu culture, and the start of the Greek culture, considered to be the origin of our Western culture. The earliest hint of a Druidic culture dates back to this time. One stream of ancient druidic lore talks of a cataclysmic event, stones pouring from the sky, raising the possibility that early stone structures and barrows were built effectively as ‘bomb shelters’7.
While the meaning of the word ‘dru’ is associated with oak (those who meet by the oak) and truth, it also may also mean worshippers of the red Sun (du rua). Sun and fire worship is shared by the early Egyptians (Ra), (dru)vedic culture (Agni and Surya), Zoroastrian culture(Mithra) and even Sumerian culture (Utu). (Please excuse my broad brush approach, and probably inaccuracies in details, complexities and dates, but I share this as my attempt to get an overview of humanity’s early cultural evolutions, still evident today in the Vedic (Hindu), Parsi (Zoroastrian) and Greek culture.)
Of course, the use of fire started much earlier, with it’s discovery a million years ago, and widespread use from 500,000 years ago, which expanded humanity’s ability to derive energy from previously indigestible carbohydrates, as evidenced in the DNA with the emergence of multiple variations in carbohydrate- digesting amylase enzymes. Cooking food allowed digestion to take place more quickly which meant the gut shortened considerably, allowing the additional energy and blood to be diverted to the expanding brain. 8 This may have been another essential pre-requisite for the emergence of our higher intelligence..
While atheists often portray religion purely as a sociological ‘control’ system, setting laws and morals for behaviour, thus having survival advantages, they deny the existence of a spiritual awareness or experience, which lies at the essence of all profound mystical philosophies. The mystical experience of a god or creative force or higher intelligence has had a profound influence of human culture. How did this come to happen? That, and the emergence of self-awareness, is the 2001 Space Odyssey question. While still denied by some, more ancient rock art experts, such as David Coulson, consider that early man may have discovered hallucinogens, capable of expanding awareness to another level. Many of the shapes and patterns and depictions are consistent with those visual distortions seen under the influence of plants containing tryptamines, such as psilocybin found in mushrooms. Could hallucinogens played in part in the evolution of our intelligence? (Stay with me on this one.)
The brain produces one hallucinogenic tryptamine, di-methyl-tryptamine (DMT), capable of producing a phenomenal expansion of awareness. It is found concentrated in the pineal gland, itself a light sensitive gland in most animals, which René Descartes considered the ‘seat of the soul’. What exactly is the function of DMT and why we evolved to make it, is an interesting question. Recent research shows that it mimics near death experiences and also induces theta waves associated with dream states. We also make other tryptamines, notably serotonin the ‘happy’ neurotransmitter and melatonin, required for sleep, being produced at night, thus keeping us in sync with the day/night cycle.
In North and South America two cacti containing mescalin grow - San pedro in the South and Peyote in the North. Mescalin, like dopamine, is a phenethylamine, not a tryptamine. When these started to be used in not really known.
Dr Fred Previk, in his book 'The Dopaminergic Mind in Human Evolution' makes a good case for our increase in intelligence being driven by a set of circumstances that increased dopamine in the left hemisphere of the brain, while serotonin predominates in the right hemisphere. All non-human species with advanced intelligence also have similarly high levels of dopamine. In other words, the biochemical changes in the software of our brains drove the evolution of intelligence, not genetics.
The set of circumstances that he thinks are likely to have contributed to more reliance on dopamine, include:
- a physiological adaptation to a thermally stressful environment (think in and out of water)
- eating more shellfish with provides dopamine precursors
- demographic pressures that increased competition for resources
Could naturally occurring hallucinogens have also played a part in the expansion of awareness interacting with our neurotransmitter enhanced mind? They certainly seem to be associated with the emergence of most ancient cultures, from the Egyptians whose priests consumed blue lily, and the Vedic priests who used soma, some kind of plant-based concoction capable of producing visions. Exactly what soma was has been a subject of much speculation. (Many plants contain DMT, but it has to be combined with an enzyme blocker to stop its breakdown on digestion. Syrian rue and the Amazonian ayahuasca vine serve this purpose.)
In the European early druidic traditions hallucinogenic plants such as mandrake and henbane have use going back thousands of years. Our own western culture owes its origins to the Greek Enlightenment 2,500 years ago. Thousands of ancient Greeks were initiated in a ceremony, the Eleusian Mysteries, which involved drinking the kykeon, a hallucinogen concoction probably derived from the ergotamine fungus, another tryptamine akin the LSD, found growing on rye in that region.
The existence of mind expanding and altering compounds being involved in an expansion of awareness and cultural paradigm shifts continues today, as we move beyond the industrial age into the digital age. What triggered this? Was it just an evolution of electronics (the hardware) or did the LSD revolution, with the epicentre in California, trigger a new conceptualisation of digitising our internal experience and perception of sight and sound and projecting our consciousness (the software) and ‘neural networks’ into the digital area? Certainly, the movers and shakers of the digital revolution talk highly of the role LSD played in their conceptualisation of digital potential. For example, Steve Jobs said that taking LSD was ‘one of the most important things’ to influence his ideas.
After decades of a complete research shut down into psychedelics John Hopkins University in the US and Imperial College in London, in collaboration with the Beckley Foundation, now have psychedelic research centres actively exploring how tryptamines work in the brain and the potential they have for alleviating mental health problems such as depression, anxiety and post-traumatic stress disorder, but also for inducing expansion of awareness, which has already shown very useful in relieving distress in people with terminal diseases. Can a resurgence in the intelligent use of psychedelics assist a cultural enlightenment? We certainly need one.
Is Homo Sapiens devolving?
Globally, there is an increase in mental illness which is fast becoming the biggest health threat, according to the World Health Organisation. There is also evidence that our brain size has reduced by 10 per cent, from 1.45kg 10,000 years ago9 to an average now of 1.35kg, coinciding with a more land-based food supply. According to Scandinavian research, our IQ is also falling by 7 per cent a generation. Global rates of depression and dementia, suicide and stress-related disorders of anxiety and insomnia are escalating. One in six children in the UK are classified with ‘special educational needs’ (SEN). Suicide, globally, has become the most cause of violent deaths, ahead of all wars and murders. In the UK 790 people a day, nine double decker buses worth, are diagnosed with dementia. Global incidence will top 100 million this decade, already costing over 1% of GDP.
On the assumption that our brains still require at least the same supply of nutrients that our semi-aquatic ancestors were able to eat during the period of maximum brain evolution - although one could argue that the digital age has put more stress on our brain function, hence we might even need more nutrients - and the fact that we are simply not achieving anything like the same intake of the brain’s essential fats, phospholipids and micronutrients, is it any wonder that mental health is in sharp decline? With a growing population and declining available seafood, coupled with contamination with heavy metals, PCBs and micro-plastic particles, matters are likely to get much worse.
High sugar intake, in animals, has been shown to lead to shrinking of the brain’s hippocampal region. This is where the nucleus accumbens, the seat of the brain’s dopamine-based ‘reward’ system, stimulated by sugar, caffeine and tech addiction, (especially that based on variable rewards such as the ‘like’ button) resides. Marketeers have learnt how to create addiction to their products by stimulating the reward system, selling short-term pleasure, the dopamine-based feeling, in the guise of happiness. The happy hour, the happy meal, happiness in a bottle etc. Over-stimulation of the reward system ultimately leads to dopamine depletion and brain cell death, coupled with a decline in serotonin, the tryptamine associated with happiness, connection, love, empathy and other essential qualities of a harmonious society – and the very qualities that make us human.
We are therefore witnessing the devolution of the brain, the decline and fall of mental health and harmonious society, a situation that is likely to get worse as population expands, unless we rapidly find a way to optimally nourish the brain.
Building Healthy Brains
The emphasis in human nutrition has, for too long, been on the body. With more protein, meat and dairy products, we have grown taller, but not smarter. As director of the Institute of Brain Chemistry at the Chelsea and Westminster Hospital, Professor Michael Crawford has been able to accurate predict which pregnant women are most likely to have pre-term babies, with an increased risk of cognitive delay or impairment. [This is based on determining the supply, by analysing the pregnant woman’s blood, of DHA. In its absence levels of a surrogate fat, a type of oleic acid, rises to fulfil the requirement of the neonatal brain, when DHA is in short supply. It is, however, an inadequate substitute and thus cognitive development is impaired. Babies born of mothers with low blood DHA levels, compared to those supplementing DHA, have smaller brains.10
According to Crawford, with a growing population and shrinking fish supply, we must develop marine agriculture on a massive scale to survive and protect the brain. In the same way that man moved from hunter gatherer on the land to peasant farmer, we too must move from hunter gatherer in the oceans to marine farmer. In Japan he has been instrumental in the creation of artificial reefs in the estuaries to attract back the marine food web, from mussels to crustaceans, and fish, as well as farming seaweed on a massive scale. By processing seaweed it is possible to create DHA, the critical brain fat that is crucially lacking in a plant-based diet. As Crawford says "We now face a world in which sources of DHA – our fish stocks – are threatened. That has crucial consequences for our species. Without plentiful DHA, we face a future of increased mental illness and intellectual deterioration. We need to face up to that urgently."
At the other end of the lifecycle, more and more older people are slipping into dementia, which is a preventable but not reversible condition. At the University of Oxford, Professor David Smith has shown that inadequate omega-3 fats (primarily DHA) and B vitamins, especially vitamin B12, are the principle drivers of cognitive decline. Yet, by providing these nutrients to those with pre-dementia, further memory decline and brain shrinkage can be arrested. B12 is only found in animal foods and is especially rich in seafood. A plant-based diet alone does not provide sufficient DHA, B12 or phospholipids require for optimal brain development.
Therefore, it is vital that the needs for optimal brain function are put at the top of the health agenda to prevent the decline of our mental health and potentially the fall of Homo Sapiens. Without our fully functioning brains humanity will neither have the insight nor cooperation to face and resolve the challenges we face with a growing population, reducing food supply, increasing pollution, climate changes and ever-increasing energy demands.
You can read more on brain nutrition in my book 'Optimum Nutrition for the Mind'. The book and brain supporting supplements formulated by me, are both stocked by HOLFORDirect.
1. Crawford, M.A. and Sinclair, A.J. (1971) Nutritional influences in the evolution of the mammalian brain. In Lipids, malnutrition and the developing brain: 267-292. Elliot, K. and Knight, J. (Eds.). A Ciba Foundation Symposium (19-21 October, 1971). Amsterdam, Elsevier. PMID: 4949878; see also Crawford, M.A. (1992) The role of dietary fatty acids in biology: their place in the evolution of the human brain. Nutr. Rev. 50: 3 - 11. ; see also Bloom M, Linseisen F, Lloyd-Smith J and Crawford MA (1999) Insights from NMR on the Functional Role of Polyunsaturated Lipids in the Brain. In: "Magnetic Resonance and Brain Function - Approaches from Physics" Proceedings of the 1998 Enrico Fermi International School of Physics, Enrico Fermi Lecture, Course #139, Varenna, Italy, pp 1-27, ed. B. Maraviglia.
2. Crawford MA, Bloom M, Broadhurst CL, Schmidt WF , Cunnane SC , Galli Ghebremeskel K, Linseisen F, Lloyd-Smith J and Parkington J (1999) Evidence for the unique function of DHA during the evolution of the modern hominid brain. Lipids 34, S39-S47; see also Crawford MA, Leigh Broadhurst C, Guest M, Nagar A, Wang Y, Ghebremeskel K, Schmidt WF (2013) A quantum theory for the irreplaceable role of docosahexaenoic acid in neural cell signaling throughout evolution Prostaglandins Leukot Essent Fatty Acids (PLEFA); 88(1):5-13. doi: 10.1016/j.plefa.2012.08.005. PMID: 23206328.
3. Crawford MA, Thabet M, Wang Y (2018). An introduction to a theory on the role of π-electrons of docosahexaenoic acid in brain function: the quantum brain. OCl, 25: A402 DOI: 10.1051/ocl/2018010; see also Crawford MA, Thabet M, Wang Y, Broadhurst C L, Schmidt WF (2018) A theory on the role of the π-electrons of docosahexaenoic acid in brain function. OCI, 24, A403. doi.org/10.1051/ocl/2018011
5. https://www.astrobio.net/news-exclusive/how-earths-orbital-shift-shaped-the-sahara/; see also https://phys.org/news/2019-01-sahara-swung-lush-conditions-years.html; see also https://www.ncdc.noaa.gov/abrupt-climate change/End%20of%20the%20African%20Humid%20Period
8. K. Hardy et al., ‘The importance of dietary carbohydrate in human evolution’, Quarterly Review of Biology(2015), vol 90(3):251–268.
10 Randomized controlled trial of brain specific fatty acid supplementation in pregnant women increases brain volumes on MRI scans of their newborn infants. Ogundipe E, Tusor N, Wang Y, Johnson MR, Edwards AD, Crawford MA. Prostaglandins Leukot Essent Fatty Acids. 2018 Nov;138:6-13. doi: 10.1016/j.plefa.2018.09.001.